Drug level monitoring may be necessary in patients who remain acid-fast bacilli smear positive after 3 months of directly observed therapy. Dosage may be titrated upwards to keep the rifampin the active ingredient contained in Rifadin level in the therapeutic range. This information should not be used to decide whether or not to take rifampin capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about rifampin capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to rifampin capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using rifampin capsules. amber probenecid probenecid
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. FDA pregnancy category C. It is not known whether methylprednisolone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Rifampin is readily absorbed from the gastrointestinal tract. Peak serum concentrations in healthy adults and pediatric populations vary widely from individual to individual. Since isoniazid is known to cross the placental barrier and to pass into maternal breast milk, neonates and breastfedinfants of isoniazid treated mothers should be carefully observed for any evidence of adverse effects.
Rifampin has bactericidal activity in vitro against slow and intermittently growing M tuberculosis organisms. Two standardized in vitro susceptibility methods are available for testing rifampin against M tuberculosis organisms. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.
If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These are meds that fight infections. You need a prescription to get them. You can take them as a pill, or you can use a cream or lotion that you spread on your skin. They can keep your symptoms from getting worse and help curb more outbreaks.
Rifampin may speed up how quickly your liver processes bupropion. PH, Smith E. The effect of rifampicin on norethisterone pharmacokinetics. Also, for children younger than 12 years, not use codeine or dihydrocodeine to treat or pain unless specifically directed by the doctor. Use of codeine or dihydrocodeine is not recommended to treat and pain in children between 12 and 18 years old who have breathing problems. Streptomycin usually is given only to people who cannot take ethambutol. Treatment should be continued for longer if the patient is still sputum or culture positive, if resistant organisms are present, or if the patient is HIV positive. Priftin rifapentine US prescribing information. Some MEDICINES MAY INTERACT with Rifadin. Liver problems may occur with this medicine. The risk for liver problems is increased if you drink alcoholic beverages on a regular basis. You should limit the amount of alcoholic beverages you drink while you are receiving this medicine. If you have any concerns about this, talk to your doctor. Leung CC, Law WS, Chang KC, et al. "Initial Experience on Rifampin and Pyrazinamide vs Isoniazid in the Treatment of Latent Tuberculosis Infection Among Patients With Silicosis in Hong Kong. The 'flu-like syndrome' generally occurs with intermittent dosing of rifampin the active ingredient contained in Rifadin in patients with poor adherence to daily rifampin therapy, and when daily rifampin is resumed after a drug free period. While some people with inflammatory types of arthritis or other rheumatic diseases may be prescribed Medrol as part of their daily treatment regimen, the Medrol dose pack is a burst of the medication taken according to a specific schedule over 6 days.
Do not stop taking rifampin capsules without checking with your doctor. Do not miss any doses. Rarely, kidney problems have occurred when patients started taking rifampin capsules again after therapy was interrupted. If necessary, gently crush the capsule contents with a spatula to produce a fine powder. What happens if I overdose? Hormonal birth control eg, birth control pills, implants, patches may not work as well while you are using Rifadin. To prevent pregnancy, use an extra form of birth control eg, condoms. Approved Standard CLSI Document M2-A10, Vol. 29, No. 1, CLSI, Villanova, PA, January 2009. Rifampin has been shown to produce liver dysfunction. Lee CH, Lee CJ "Thrombocytopenia: a rare but potentially serious side effect of initial daily and interrupted use of rifampicin. Rifampicin is also available as syrup for children. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Some MEDICINES MAY INTERACT with rifampin capsules. Store the capsules at room temperature away from light and moisture. The liquid form may be stored at room temperature or refrigerated for up to 4 weeks. Do not store in the bathroom. Keep all medications away from children and pets. Rifadin 300mg Capsules just because you feel better. Rifampin has been shown to produce liver dysfunction. Fatalities associated with jaundice have occurred in patients with liver disease and in patients taking rifampin with other hepatotoxic agents. Patients with impaired liver function should be given rifampin only in cases of necessity and then with caution and under strict medical supervision. acticin
Gastrointestinal side effects have included nausea and dyspepsia in 2% of patients. Heartburn, anorexia, vomiting, flatulence, cramps and diarrhea have also been observed. Isoniazid is metabolized primarily by acetylation and dehydrazination. The rate of acetylation is genetically determined. Tahan SR, Diamond JR, Blank JM, Horan RF "Acute hemolysis and renal failure with rifampicin-dependent antibodies after discontinuous administration. Each capsule contains 300mg of the active ingredient, rifampicin. Will I need surgery? Rifadin may produce a reddish coloration of your urine, sweat, saliva, and tears. Rifadin may also permanently stain soft contact lenses. There are a lot of different antibiotics that your doctor can recommend. Nervous system reactions: peripheral neuropathy is the most common toxic effect. This list is not complete and other drugs may interact with methylprednisolone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Metabolic reactions: elevations in BUN and serum uric acid have occurred. KEEP OUT OF THE SIGHT AND REACH OF CHILDREN. Mariette X, Mitjavila MT, Moulinie JP, et al "Rifampicin-induced pure red cell aplasia.
B12 possibly causing false test results. Rifampin may also make it harder for your body to get rid of certain chemicals used in gallbladder tests. Make sure laboratory personnel and all your doctors know you use this drug. Multiple-drug therapy to treat TB means taking several different at the same time. This is the first choice of treatment for TB that is growing in your body active TB disease. Most of these medicines are given as pills. The American Thoracic Society, Centers for Disease Control and Prevention, and the Infectious Diseases Society of America recommend using one of several combinations of the first-choice medicines to start treatment. Gastrointestinal reactions: nausea, vomiting, and epigastric distress. Petechiae associated with thrombocytopenia may occur in 1% of patients who are receiving rifampin the active ingredient contained in Rifadin Rifampin antibodies have been demonstrated in some of these patients. Thrombocytopenia is seen most frequently in patients receiving weekly therapy or after a lapse in therapy, but has also been reported during daily therapy. Decreased hemoglobin and transient leukopenia have been reported in patients who had chronic diseases and in whom other medications were given, which made it difficult to definitively determine if these adverse effects were due to rifampin. The presence of other medical problems may affect the use of this medicine. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. albendazole pills purchase online visa
Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. This product may contain codeine or dihydrocodeine. Codeine and dihydrocodeine are changed into strong drugs or dihydromorphine in your body. In some people this happens faster and more completely than usual, which increases the risk of very seriousside effects. The possibility of rapid emergence of resistant meningococci restricts the use of Rifadin to short-term treatment of the asymptomatic carrier state. Rifadin is not to be used for the treatment of meningococcal disease. What are the possible side effects of rifampin Rifadin? Separate doses by 8 to 12 hours if taking an oral aminosalicylic acid. You should check with your doctor or pharmacist if you are not sure. Adults: Two Rifampin and Isoniazid Capsules, USP 600 mg rifampin, 300 mg isoniazid once daily, administeredone hour before or two hours after a meal. There are many things you can do that are a big part of managing your skin problems. Try these tips to make your HS less severe and lower the number of outbreaks you get. Rarely, hemolysis, hemoglobinuria, hematuria, renal insufficiencyor acute renal failure, have been reported which are generally considered to be hypersensitivity reactions. This drug is not indicated for the treatment of meningococcal infections or asymptomatic carriers of N. meningitides to eliminate meningococci from the nasopharynx. C for four weeks. This extemporaneously prepared suspension must be shaken well prior to administration. Medrol has not been adequately evaluated in pregnant women. Let your doctor know if you are planning to become pregnant or if you do become pregnant while taking Medrol.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. This antibiotic treats only bacterial infections. Rifampin is widely distributed throughout the body. It is present in effective concentrations in many organs and body fluids, including cerebrospinal fluid. Rifampin is about 80% protein bound. Most of the unbound fraction is not ionized and therefore diffuses freely into tissues. Your doctor injects this medicine into the bumps. It can ease inflammation, pain, and swelling. You usually get these shots once a month for up to 3 months. Your doctor will need to check your blood before you take this medicine. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adults: For adults, it is recommended that 600 mg rifampin be administered twice daily for two days. Rifampin is contraindicated in patients who are also receiving ritonavir-boosted saquinavir due to an increased risk of severe hepatocellular toxicity. If a bump is leaking, make sure the bandage you put on it doesn't stick to your skin. Use plenty of petroleum jelly on the gauze that covers the area. Avoid using adhesive tape as much as possible. Store the capsules at room temperature away from light and moisture. The liquid form may be stored at room temperature or refrigerated for up to 4 weeks. not store in the bathroom. Keep all away from children and pets. What should I discuss with my healthcare provider before using Rifadin rifampin? Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. After being admitted to the hospital with multiple symptoms of tuberculosis, the patient was prescribed rifampin, isoniazid, pyrazinamide, and ethambutol. Two hours after taking the first pill of rifampin 600 mg the patient developed anaphylactic shock, liver injury, hemolytic anemia, acute renal failure, and disseminated intravascular coagulation. Direct and indirect antiglobulin Coombs tests were positive. RFP-dependent IgG and IgM antibodies with complement fixing capability were observed in the serum. The patient was transferred to the intensive care unit and underwent hemodialysis. Clinical recovery and return of laboratory data to normal levels occurred over a 5-week period. The patient was subsequently given isoniazid, pyrazinamide, ethambutol, ciprofloxacin, and recovered from tuberculosis. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Tenderness or soreness in your belly. Brownish-red or orange discoloration of the skin, urine, sweat, saliva, tears, and feces will occur, and its intensity is proportional to the amount ingested. purchase now generic xeloda online
The amount of etravirine or nevirapine in your blood may decrease and it may not work as well against your HIV infection. Chan CH, Chong YW, Sun AJ, Hoheisel GB "Cutaneous vasculitis associated with tuberculosis and its treatment. This section provides information on the proper use of a number of products that contain rifampin. It may not be specific to Rifadin. Please read with care. The risk of hepatitis is increased with daily consumption of alcohol. These measures will help to protect the environment. Dermatologic side effects have included cutaneous reactions that are mild and self-limiting and usually not associated with a hypersensitivity to rifampin the active ingredient contained in Rifadin These reactions generally manifest as itching and flushing with or without rash. Serious dermatologic reactions that resulted from hypersensitivity have been reported rarely. Heartburn, epigastric distress, anorexia, nausea, vomiting, jaundice, flatulence, cramps, and diarrhea have been noted in some patients. Although Clostridium difficile has been shown in vitro to be sensitive to rifampin, pseudomembranous colitis has been reported with the use of rifampin and other broad spectrum antibiotics. Therefore, it is important to consider this diagnosis in patients who develop diarrhea in association with antibiotic use. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Rifampin will cause urine, stool, saliva, sputum, sweat, and tears to turn a reddish-orange to reddish-brown color. This is to be expected while you are using this medicine, and everything will return to normal once you stop using it. This effect may cause soft contact lenses to become permanently discolored, so it is best not to wear soft contact lenses while you are using this medicine. If you or your child have any questions about this, check with your doctor. Your pharmacist can provide more information about rifampin. In some cases, hyperbilirubinemia resulting from competition between rifampin and bilirubin for excretory pathways of the liver at the cell level can occur in the early days of treatment. Taking Rifadin 300mg Capsules may affect the results of some blood tests. There are many reasons why people have trouble taking their medicine. Assendelft AH "Renal failure and haemolysis caused by rifampicin. You wear contact lenses. Dose is based on body weight and must be determined by your doctor. The dose is 10 milligrams mg per kilogram kg of body weight once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 600 mg per day. Dark colored urine can be a sign of liver problems. Call your doctor if you have reddish-brown urine together with upper stomach pain, loss of appetite, and jaundice yellowing of your skin or eyes. Rifampin is widely distributed throughout the body. It is present in effective concentrations in many organs and body fluids, including cerebrospinal fluid. Rifampin is about 80% protein bound. Most of the unbound fraction is not ionized and, therefore, diffuses freely into tissues. micronase
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. If you have any questions about rifampin capsules, please talk with your doctor, pharmacist, or other health care provider. Before taking rifampin, tell your doctor if you are allergic to any drugs, or if you have liver disease or porphyria a genetic enzyme disorder that causes symptoms affecting the skin or nervous system. Rifadin only works against bacteria; it does not treat viral infections eg, the common cold. These may be symptoms of a serious medical problem and should be checked by a doctor. These are generally considered to be hypersensitivity reactions. Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up a missed dose. Therefore, patients given isoniazid should be carefully monitored and interviewed at monthly intervals. Serum transaminase concentration becomes elevated in about 10-20 percent of patients, usually during the first few months of therapy, but it can occur at any time. Usually enzyme levels return to normal despite continuance of drug, but in some cases progressive liver dysfunction occurs. Patients should be instructed to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid should be discontinued promptly, since continued use of the drug in these cases has been reported to cause a more severe form of liver damage. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. The amount of bupropion in your blood may decrease and it may not work as well. Children may sit in a "sniffing position" with the body leaning forward and the head and nose tilted forward and upward. To help prevent this effect, drink plenty of fluids unless otherwise directed by your doctor. If you are unable to swallow rifampin capsules whole, your pharmacist may be able to make a liquid form of rifampin capsules. Talk with your pharmacist if you have questions.
Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed. This will lessen the chances of becoming addicted. Other types of epiglottitis are caused by heat damage. The patient should be told that rifampin may produce a reddish coloration of the urine, sweat, sputum, and tears, and the patient should be forewarned of this. Soft contact lenses may be permanently stained. Therefore, concomitant use of these medications is contraindicated. Because manipulation of the epiglottis may result in sudden fatal airway obstruction and because irregular slow heart rates have occurred with attempts at intubation putting a tube down the throat and placing the person on a machine that helps with breathing the doctor will likely use the controlled environment of an operating room or intensive care unit to see the throat structures. The bumps and leaky pockets can go away and come back. In severe cases, they don't fully heal. Before using this medication, women of childbearing age should talk with their doctors about the risks and benefits. Tell your doctor if you are or if you plan to become pregnant. What should I avoid while taking Rifadin IV rifampin? For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Each pack contains 56 Capsules. Patients using oral or other systemic hormonal contraceptives should be advised to change to nonhormonal methods of birth control during rifampin therapy. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Do not take if any of the above apply to you. Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterialRNA polymerase but does not inhibit the mammalian enzyme. This is the mechanism of action by which rifampinexerts its therapeutic effect. Rifampin cross resistance has only been shown with other rifamycins. After three weeks of incubation MIC 99 values are calculated by comparing the quantity of organisms growing in the medium containing drug to the control cultures. Mycobacterial growth in the presence of drug, of at least 1% of the growth in the control culture, indicates resistance. terazosin generic equate
Store this medication at room temperature away from moisture and heat. What other drugs will affect Rifadin IV rifampin? Rifampin may also be used for other purposes not listed in this medication guide. This can ease your symptoms by reducing the surfaces where you skin rubs together. That way you'll have fewer flare-ups. Rifampin and pyrazinamide are used with two other medicines to treat tuberculosis TB. They are also used together without other agents to prevent TB. When they are used together to prevent TB, they can damage your liver. Your risk of having liver damage from using these medicines together may be greater if you already have some liver problems, if you are taking other medicines that can damage your liver, if you developed liver damage while taking isoniazid another medicine for TB or if you are an alcoholic. How long ago did your symptoms begin? Product Information. Rifadin rifampin. Fitzgerald D, et al. 2010. Mycobacterium tuberculosis. Do not wear contact lenses while you are taking rifampin. This medicine may discolor your tears, which could permanently stain soft contact lenses. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Various organisms that can cause epiglottitis include pneumoniae, Haemophilus parainfluenzae, varicella-, type 1, and Staphylococcus aureus, and others. Murray AN, Cassidy MJ, Templecamp C "Rapidly progressive glomerulonephritis associated with rifampicin therapy for pulmonary tuberculosis.
Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA "Acute renal failure due to rifampicin: a study of 25 patients. The bumps can get infected. When that happens, pockets form under the skin and fill with pus that smells bad when they break open. They can leave scars, too. To keep new bumps from forming, get treatment as soon as you can. Have you had these symptoms in the past? Rare reports of have also been observed. Quantitative methods that require measurement of zonediameters give the most precise estimates of antibiotic susceptibility. One such procedure has been recommendedfor use with discs for testing susceptibility to rifampin. Interpretations correlate zone diameters from the disc testwith MIC minimal inhibitory concentration values for rifampin. Bactroban cream is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in any of these areas, rinse well with cool water. Absorption of rifampin is reduced by about 30% when the drug is ingested with food. Store rifampin capsules at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tightly closed container, away from heat, moisture, and light. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. This information should not be used to decide whether or not to take Rifadin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Rifadin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Rifadin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Rifadin. Keep this leaflet. You may need to read it again. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Abuscreen OnLine opiates assay; Roche Diagnostic Systems. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Rifampin is not recommended for intermittent therapy; the patient should be cautioned against intentional or accidental interruption of the daily dosage regimen since rare renal hypersensitivity reactions have been reported when therapy was resumed in such cases. uvik.info effexor
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The information contained in the Truven Health Micromedex products as delivered by Drugs. Miscellaneous reactions: rheumatic syndrome and systemic lupus erythematosus-like syndrome. PH, Smith E, Watts MJ. The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women. Rifampin should not be used indiscriminately, and therefore, diagnostic laboratory procedures, including serotyping and susceptibility testing, should be performed for establishment of the carrier state and the correct treatment. So that the usefulness of rifampin in the treatment of asymptomatic meningococcal carriers is preserved, the drug should be used only when the risk of meningococcal disease is high. cheap lisinopril purchase online payment lisinopril
How mild or severe is my hidradenitis suppurativa? Psychiatric side effects have rarely included psychoses. Liver enlargement, possibly with tenderness, can develop within a few hours after severe overdosage; bilirubin levels may increase and jaundice may develop rapidly. Hepatic involvement may be more marked in patients with prior impairment of hepatic function. Other physical findings remain essentially normal. A direct effect upon the hematopoietic system, electrolyte levels, or acid-base balance is unlikely.
What should I discuss with my healthcare provider before using rifampin Rifadin? WARNINGS section for information regarding patients with hepatic insufficiency. Rifampin is not recommended for intermittent therapy; the patient should be cautioned against intentional oraccidental interruption of the daily dosage regimen since rare renal hypersensitivity reactions have been reportedwhen therapy was resumed in such cases. Burman WJ, Gallicano K, Peloquin C "Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. H37Rv ATCC 27294 as a control organism.
Quantitative methods that are used to determine minimum inhibitory concentrations provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. Levine M, Collin K, Kassen BO "Acute hemolysis and renal failure following discontinuous use of rifampin. HS less severe. Talk to your doctor about finding programs that can help you break the habit. Use with caution. May make these conditions worse. Previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid, such as drug fever, chills, andarthritis; acute liver disease of any etiology. A history of previous hypersensitivity reaction to any of the rifamycinsor to isoniazid, including drug-induced hepatitis.